Conclusion
Aspartame consumption is not associated with adverse effects in the general population. Studies have found no evidence of an effect of aspartame on a wide range of adverse effects including hypersensitivity reactions, elevated blood methanol or formate levels, hematopoeitic or brain cancers. Neurological changes tested included cognitive functions, seizures, headaches and changes in memory or mood.
Grade I
Overall strength of the available supporting evidence: Grade I - good; Grade II - fair; Grade III - limited; Grade IV - expert opinion; Grade V: not assignable
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Date of Literature Review for the Evidence Analysis: February 2008
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